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Novel Mediator proteins of the small mediator complex in Drosophila SL2 cells

Title
Novel Mediator proteins of the small mediator complex in Drosophila SL2 cells
Authors
Gu J.-Y.Park J.M.Song E.J.Mizuguchi G.Yoon J.H.Kim-Ha J.Lee K.-J.Kim Y.-J.
Ewha Authors
이공주
SCOPUS Author ID
이공주scopus
Issue Date
2002
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258JCR Link
Citation
vol. 277, no. 30, pp. 27154 - 27161
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The Mediator complex is generally required for transcriptional regulation in species ranging from yeast to human. Throughout evolution, the functional diversity of the Mediator complex has been enhanced to meet the increasing requirements for sophisticated gene regulation. It is likely that greater structural complexity is thus required to accomplish these new, complex regulatory functions. In this study, we took systematic steps to examine various types of Mediator complexes in Drosophila melanogaster. Such efforts led to the identification of three distinct forms of Mediator complexes. In exploring their compositional and functional heterogeneity, we found that the smallest complex (Cl) is highly enriched in a certain type of Drosophila cells and possesses novel Mediator proteins. The subunits shared among the three Mediator complexes (C1, C2, and C3) appear to form a stable modular structure that serves as a binding surface for transcriptional activator proteins. However, only C2 and C3 were able to support activated transcription in vitro. These findings suggest that different cell types may require distinct Mediator complexes, some of which may participate in nuclear processes other than the previously identified functions.
DOI
10.1074/jbc.M204144200
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약학대학 > 약학과 > Journal papers
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