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Sol-Gel transition temperature of PLGA-g-PEG aqueous solutions

Title
Sol-Gel transition temperature of PLGA-g-PEG aqueous solutions
Authors
Chung Y.-M.Simmons K.L.Gutowska A.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2002
Journal Title
Biomacromolecules
ISSN
1525-7797JCR Link
Citation
vol. 3, no. 3, pp. 511 - 516
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Aqueous solutions of poly(DL-lactic acid-co-glycolic acid)-g-poly(ethylene glycol) copolymers exhibited sol-to-gel transition with increasing temperature. Further increase in temperature makes the system flow and form a sol phase again. Subcutaneous injection of a copolymer aqueous solution (0.5 mL) resulted in a formation of a hydrogel depot by temperature-sensitive sol-to-gel transition in a rat model. The reliable determination and control of sol-to-gel transition temperatures are the most important issues for this kind of sol-gel reversible hydrogel. The sol-to-gel transition temperature determined by the test tube inverting method, falling ball method, and dynamic mechanical analysis coincided within 1-2 °C. Fine tuning of the sol-to-gel transition temperature was achieved by varying the ionic strength of the polymer solutions and by mixing two polymer aqueous solutions with different sol-to-gel transition temperatures. The sol-to-gel transition temperature of polymer mixture aqueous solutions was well described by an empirical equation of miscible blends, indicating miscibility of the two polymer systems in water on the molecular level.
DOI
10.1021/bm0156431
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자연과학대학 > 화학·나노과학전공 > Journal papers
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