Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최원자 | - |
dc.date.accessioned | 2016-08-28T11:08:55Z | - |
dc.date.available | 2016-08-28T11:08:55Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0749-503X | - |
dc.identifier.other | OAK-969 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218952 | - |
dc.description.abstract | Nikkomycin Z is a competitive inhibitor of chitin synthases in fungi. It has been reported that it inhibits chitin synthases (Chs) 1 and 3, but not 2, of Saccharomyces cerevisiae. In our study, we found that: (a) nikkomycin Z inhibited all three Chs isozymes of Candida albicans (CaChs). The IC 50 value for CaChs1 is 15 μM, for CaChs2 0.8 μM, and for CaChs3 13 μM; (b) nikkomycin Z inhibits vegetative growth of C. albicans differently in different growth media; growth inhibition was observed on Spider and corn meal agar plate, but not on Lee's plate; (c) growth inhibition by nikkomycin Z accompanied by the absence of septum and cell wall chitin, which in turn brought about cell lysis. Nikkomycin Z did not lyse cells in Lee's media and lysis was partially prevented in the presence of sorbitol as an osmostabilizer in Spider medium. Therefore, nikkomycin Z prevented the formation of septum and cell wall chitin by inhibiting chitin synthase activities in a growth medium-dependent manner. Copyright © 2002 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.title | Inhibitory effect of nikkomycin Z on chitin synthases in Candida albicans | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 19 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 341 | - |
dc.relation.lastpage | 349 | - |
dc.relation.journaltitle | Yeast | - |
dc.identifier.doi | 10.1002/yea.837 | - |
dc.identifier.wosid | WOS:000174237900005 | - |
dc.identifier.scopusid | 2-s2.0-0037087290 | - |
dc.author.google | Kim M.-K. | - |
dc.author.google | Park H.-S. | - |
dc.author.google | Kim C.-H. | - |
dc.author.google | Park H.-M. | - |
dc.author.google | Choi W. | - |
dc.contributor.scopusid | 최원자(7402515987) | - |
dc.date.modifydate | 20230210130537 | - |