Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T11:08:55Z | - |
dc.date.available | 2016-08-28T11:08:55Z | - |
dc.date.issued | 2002 | * |
dc.identifier.issn | 0032-0943 | * |
dc.identifier.other | OAK-968 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218951 | - |
dc.description.abstract | A prenylated coumarin, osthenol (1) and a sesquiterpene, bisabolangelone (2) have been isolated as active principles with 5α-reductase type 1 inhibitory effects in LNCaP cells from the roots of Angelica koreana Max. by bioassay-guided chromatographic fractionation. Osthenol exhibited a highly potent inhibitory activity on 5α-reductase type I in LNCaP cells with an IC50 value of 0.1 μg/ml, which is about 200 times more potent than the positive control, finasteride (IC50 = 19.8 μg/ml). Bisabolangelone also inhibited the activity of 5α-reductase type I in LNCaP cells (IC50 = 11.6 μg/ml), indicating that these compounds are possible candidates for the development of new drugs to treat human endocrine disorders associated with overproduction of DHT by 5α-reductase type I. In addition, four compounds isooxypeucedanin, oxypeucedanin hydrate, oxypeucedanin and isoimperatorin were also isolated and found to be inactive in the 5α-reductase assay systems used in the present study. | * |
dc.language | English | * |
dc.title | Inhibitors of 5α-reductase type I in LNCaP cells from the roots of Angelica koreana | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 68 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 162 | * |
dc.relation.lastpage | 163 | * |
dc.relation.journaltitle | Planta Medica | * |
dc.identifier.doi | 10.1055/s-2002-20258 | * |
dc.identifier.wosid | WOS:000174160000015 | * |
dc.identifier.scopusid | 2-s2.0-0036178199 | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Kyeong H.K. | * |
dc.author.google | Min K.K. | * |
dc.author.google | Cho M.-H. | * |
dc.author.google | Choi E. | * |
dc.author.google | Kim K. | * |
dc.author.google | Mar W. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |