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Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol

Title
Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol
Authors
Ji Y.K.Lee K.-W.Kim S.-H.Jae J.W.Kim Y.-S.Hyong J.L.
Ewha Authors
김영석
SCOPUS Author ID
김영석scopus
Issue Date
2002
Journal Title
Planta Medica
ISSN
0032-0943JCR Link
Citation
vol. 68, no. 2, pp. 119 - 122
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Panaxytriol, a polyacetylenic compound, isolated from red ginseng (Panax ginseng C.A. Meyer), was studied to determine its effects on the growth and cell cycle of tumor cell lines. The compound showed both significant cytotoxicity and inhibition of DNA syntheses in various tumor cells tested. For P388D1, a mouse lymphoma cell line, IC50 values for cytotoxicity and inhibition of DNA synthesis were 3.1 and 0.7 μg/ml, respectively. The cytotoxic effect of panaxytriol was both time- and dose-dependent. It also induced the cell cycle arrest of P388D1 at the G2/M phase, which was measured through flow cytometry. Particularly, the proportion of cells in the G2/M phase of the cell cycle increased from 9% to 26 and 48%, respectively, after 24 and 36 h exposure to panaxytriol at 5 μg/ml. There were corresponding decreases in the proportion of cells at the G0/G1 phase. The S phase also decreased during the 36-h treatment.
DOI
10.1055/s-2002-20240
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엘텍공과대학 > 식품공학전공 > Journal papers
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