View : 19 Download: 0

Synthesis of novel D-2′-Deoxy-2′-C-difluoromethylene-4′-thiocytidine as a potential antitumor agent

Title
Synthesis of novel D-2′-Deoxy-2′-C-difluoromethylene-4′-thiocytidine as a potential antitumor agent
Authors
Lim M.H.Kim H.O.Moon H.R.Chun M.W.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2002
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 4, no. 4, pp. 529 - 531
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
(formula presented) 2′-Deoxy-2′-C-difluoromethylene-4′-thiocytidine (4) as a potential antitumor agent was synthesized starting from L-xylose via 2-deoxy-2-C-difluoromethylene-4-thiosugar as a key intermediate. An elimination product, 8, was always formed as the major product during removal of the protecting groups under acidic or basic conditions. However, utilizing neutral reaction conditions to remove the protecting groups afforded the desired product 4 exclusively.
DOI
10.1021/ol017112v
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE