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Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)

Title
Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)
Authors
Lee N.K.Lee S.Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2002
Journal Title
Journal of Biochemistry and Molecular Biology
ISSN
1225-8687JCR Link
Citation
vol. 35, no. 1, pp. 61 - 66
Indexed
SCOPUS WOS scopus
Abstract
The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-κB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.
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자연과학대학 > 생명과학전공 > Journal papers
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