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Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

Title
Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates
Authors
Kim Y.-S.Kim K.M.Song R.Jun M.J.Sohn Y.S.
Ewha Authors
손연수
SCOPUS Author ID
손연수scopus
Issue Date
2001
Journal Title
Journal of Inorganic Biochemistry
ISSN
0162-0134JCR Link
Citation
vol. 87, no. 3, pp. 157 - 163
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH2)(dmso)X2] and cis-[Pt(Q″-en)X2], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line. © 2001 Elsevier Science B.V. All rights reserved.
DOI
10.1016/S0162-0134(01)00345-2
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자연과학대학 > 화학·나노과학전공 > Journal papers
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