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Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.

Title
Effects of 6-arylamino-5,8-quinolinediones and 6-chloro-7-arylamino-5,8-isoquinolinediones on NAD(P)H: quinone oxidoreductase (NQO1) activity and their cytotoxic potential.
Authors
Ryu C.K.Jeong H.J.Lee S.K.You H.J.Choi K.U.Shim J.Y.Heo Y.H.Lee C.O.
Ewha Authors
유충규이상국
SCOPUS Author ID
유충규scopus
Issue Date
2001
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 24, no. 5, pp. 390 - 396
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Synthesized 6-arylamino-5,8-quinolinediones 4a-4j and 6-chloro-7-arylamino-5,8-isoquinolinediones 5a-5g were evaluated for effects on NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 5,8-quinolinediones 4 and 5,8-isoquinolinediones 5 affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 4a, 5c, 5f, and 5g were considered as more potent cytotoxic agents. The compounds 4d, 5b, 5c, 5e and 5g were comparable modulators of NQO1 activity.
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약학대학 > 약학과 > Journal papers
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