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Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women

Title
Correlation of plasma homocysteine and mitochondrial DNA content in peripheral blood in healthy women
Authors
Lim S.Seon Kim M.Soo Park K.Ho Lee J.Hee An G.Ja Yim M.Song J.Kim Pak Y.Kyu Lee H.
Ewha Authors
임미자
SCOPUS Author ID
임미자scopus
Issue Date
2001
Journal Title
Atherosclerosis
ISSN
0021-9150JCR Link
Citation
vol. 158, no. 2, pp. 399 - 405
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Hyperhomocysteinemia is an independent risk factor of cardiovascular disease and associated with insulin resistance, although their causal relationship remains unclear. A previous report has shown that high concentration of homocysteine damages mitochondrial gene expression, function and structure. As we found recently, the mitochondrial DNA (mtDNA) contents are inversely correlated with insulin resistance parameters. Thus there is possibility that plasma total homocysteine (tHcy) level is somewhat correlated with mtDNA content. Sixty healthy women (mean age 40.3±20.9 yr, range 18-78 yr) were recruited to investigate the correlation of plasma tHcy level and mtDNA content in peripheral blood. A significant negative correlation was found between plasma tHcy levels and mtDNA content (r=-0.507, P<0.01). Plasma tHcy and mtDNA content have an independent effect on each other and on insulin resistance (HOMA-insulin resistance (IR) score) respectively in multiple regression model. Plasma tHcy showed positive correlations with age (r=0.407), W/H ratio (r=0.370), total cholesterol (r=0.338), LDL-cholesterol (r=0.317) and insulin resistance (HOMA-IR score) (r=0.261); and a negative correlation with folate (r=-0.273). MtDNA content showed negative correlations with age (r=-0.407), BMI (r=-0.440), W/H ratio (r=-0.659), SBP (r=-0.350), total cholesterol (r=-0.340), triglyceride (r=-0.376), LDL-cholesterol (r=-0.349), fasting plasma insulin (r=-0.483), and insulin resistance (HOMA-IR score) (r=-0.423); and a positive correlation with folate (r=0.299). In this study, there was a significant inverse correlation between plasma tHcy level and mtDNA content. Further study will be warranted to elucidate the mechanism by which two factors are associated. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
DOI
10.1016/S0021-9150(01)00436-1
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신산업융합대학 > 체육과학부 > Journal papers
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