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Synthesis and antiviral activity of D- and L-2′-azido-2′,3′-dideoxy-4′-thiopyrimidine and purine nucleosides

Title
Synthesis and antiviral activity of D- and L-2′-azido-2′,3′-dideoxy-4′-thiopyrimidine and purine nucleosides
Authors
Jeong L.S.Kim Y.H.Kim H.O.Yoo S.J.Park Y.H.Yeon S.H.Chun M.W.Kim H.-D.
Ewha Authors
정낙신
Issue Date
2001
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 20, no. 4-7, pp. 665 - 668
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Novel D- and L-2′-azido-2′,3′-dideoxy-4′-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 μg/ml.
DOI
10.1081/NCN-100002346
Appears in Collections:
약학대학 > 약학과 > Journal papers
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