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Synthesis and antiviral activity of D- and L-2′-azido-2′,3′-dideoxy-4′-thiopyrimidine and purine nucleosides
- Title
- Synthesis and antiviral activity of D- and L-2′-azido-2′,3′-dideoxy-4′-thiopyrimidine and purine nucleosides
- Authors
- Jeong L.S.; Kim Y.H.; Kim H.O.; Yoo S.J.; Park Y.H.; Yeon S.H.; Chun M.W.; Kim H.-D.
- Ewha Authors
- 정낙신
- SCOPUS Author ID
- 정낙신
- Issue Date
- 2001
- Journal Title
- Nucleosides, Nucleotides and Nucleic Acids
- ISSN
- 1525-7770
- Citation
- Nucleosides, Nucleotides and Nucleic Acids vol. 20, no. 4-7, pp. 665 - 668
- Indexed
- SCIE; SCOPUS
- Document Type
- Conference Paper
- Abstract
- Novel D- and L-2′-azido-2′,3′-dideoxy-4′-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 μg/ml.
- DOI
- 10.1081/NCN-100002346
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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