Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-28T11:08:42Z | - |
dc.date.available | 2016-08-28T11:08:42Z | - |
dc.date.issued | 2001 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-730 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218814 | - |
dc.description.abstract | Previous work has implicated that the core protein of hepatitis C virus (HCV) may play a modulatory effect on NF-κB activation induced by TNF-α. However, it is unclear how HCV core protein modulates TNF-α-induced NK-κB activation. Here we show that overexpression of HCV core protein potentiates NF-κB activation induced by TNF-α. Expression of dominant negative form of TRAF2 inhibits the synergistic effects of HCV core protein on NF-κB activation, suggesting that HCV core protein potentiates NF-κB activation through TRAF2. Moreover, we demonstrate that HCV core protein potentiates TRAF2-mediated NF-κB activation via IKKβ. In addition, HCV core protein associates with TNF-R1-TRADD-TRAF2 signaling complex, resulting in synergistically activation of NF-κB induced by TNF-α. Thus, these observations indicate that HCV core protein may play an important role in the regulation of the cellular inflammatory and immune responses through NF-κB. © 2001 Academic Press. | * |
dc.language | English | * |
dc.title | Hepatitis C virus core protein potentiates TNF-α-induced NF-κB activation through TRAF2-IKKβ-dependent pathway | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 284 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 15 | * |
dc.relation.lastpage | 19 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1006/bbrc.2001.4936 | * |
dc.identifier.wosid | WOS:000169232500003 | * |
dc.identifier.scopusid | 2-s2.0-0034805144 | * |
dc.author.google | Chung Y.M. | * |
dc.author.google | Park K.J. | * |
dc.author.google | Choi S.Y. | * |
dc.author.google | Hwang S.B. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |