Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배윤수 | * |
dc.date.accessioned | 2016-08-28T11:08:39Z | - |
dc.date.available | 2016-08-28T11:08:39Z | - |
dc.date.issued | 2001 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-664 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218777 | - |
dc.description.abstract | Insulin-like growth factor-I (IGF-I) regulates muscle differentiation through phosphatidylinositol 3-kinase (PI 3-kinase). Also it was recently reported that PI 3-kinase is involved in the activation of phospholipase C-γ1 (PLC-γ1). We investigated whether PLC-γ1 therefore plays a role in IGF-I-induced muscle differentiation using H9c2 rat cardiac myoblasts as a model. IGF-I was able to activate PLC-γ1 via both PI 3-kinase-dependent and tyrosine phosphorylation-dependent mechanisms in this model. However, PI 3-kinase appeared to play a more important role than tyrosine phosphorylation in IGF-I activation of PLC-γ1. In addition, PLC-γ1 activation was independent of Akt/protein kinase B (Akt/PKB). Importantly, PLC-γ1 was involved in IGF-I-induced muscle differentiation in parallel with Akt/PKB. Taken together, these results suggest that IGF-I regulation of muscle differentiation is dependent on the activation of PLC-γ1 and Akt/PKB, both of which are downstream mediators of PI 3-kinase. © 2001 Academic Press. | * |
dc.language | English | * |
dc.title | Role of phospholipase C-γ1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 282 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 816 | * |
dc.relation.lastpage | 822 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1006/bbrc.2001.4644 | * |
dc.identifier.wosid | WOS:000168092000027 | * |
dc.identifier.scopusid | 2-s2.0-0034814451 | * |
dc.author.google | Hong F. | * |
dc.author.google | Moon K.-A. | * |
dc.author.google | Kim S.S. | * |
dc.author.google | Kim Y.S. | * |
dc.author.google | Choi Y.K. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Suh P.G. | * |
dc.author.google | Ryu S.H. | * |
dc.author.google | Choi E.-J. | * |
dc.author.google | Ha J. | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.date.modifydate | 20240415133331 | * |