View : 13 Download: 0

Molded porous poly (L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release

Title
Molded porous poly (L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release
Authors
Lee S.J.Park Y.J.Park S.N.Lee Y.M.Seol Y.J.Ku Y.Chung C.P.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2001
Journal Title
Journal of Biomedical Materials Research
ISSN
0021-9304JCR Link
Citation
vol. 55, no. 3, pp. 295 - 303
Indexed
SCOPUS WOS scopus
Abstract
The aim of this study was to develop platelet-derived growth factor (PDGF-BB) loaded moldable porous poly (L-lactide) (PLLA)-tricalcium phosphate (TCP) membranes for guided bone regeneration (GBR) therapy. The membranes were designed to fit various types of bone defect sites. PDGF-BB-dissolved PLLA-TCP in methylene chloride-ethyl acetate solution was cast on a dome shaped metallic mold to fabricate a model membrane. The release rate of PDGF-BB, the osteoblast attachment test, and guided bone regeneration potential were evaluated with PDGF-BB-loaded PLLA-TCP membranes. Regular pores were generated throughout the membrane mainly due to phase inversion of PLLA-methylene chloride-ethyl acetate solution. A therapeutic amount of PDGF-BB was released from the membrane. The release rate could be controlled by varying the initial loading content of PDGF-BB. A significant amount of cells attached onto the PDGF-BB-loaded membrane rather than onto the unloaded membrane. Dome shaped bone formation was achieved in rabbit calvaria at 4 weeks. This indicated that restoration of bone defects to the bone's original shape can be made possible by using molded membranes, which guide bone regeneration along with providing sufficient spaces. Bone forming efficiency was increased remarkably due to PDGF-BB release from PLLA-TCP membranes. These results suggested that the PDGF-BB releasing molded PLLA-TCP membrane may potentially improve GBR efficiency in various types of bone defects. © 2001 John Wiley & Sons, Inc.
DOI
10.1002/1097-4636(20010605)55:3&lt295::AID-JBM1017&gt3.0.CO2-W
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE