Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-28T11:08:37Z | - |
dc.date.available | 2016-08-28T11:08:37Z | - |
dc.date.issued | 2001 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-626 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218757 | - |
dc.description.abstract | Tumor necrosis factor (TNF) signaling leads to pleiotropic responses in a wide range of cell types, in part by activating antiapoptotic and proapoptotic pathways. Previous studies have suggested that TNF receptor-associated factor (TRAF) 2 can mediate crucial antiapoptotic signals during TNF stimulation. However, it is unclear how the antiapoptotic signals via TRAF2 in TNF-R1 signaling is regulated. Here we show that TRAF1 is cleaved by caspase-8 into two fragments during apoptosis induced by TNF. Overexpression of the C-terminal cleavage product, TRAF1-c, increased TNF-induced cell death of hybridoma T cells. Importantly, we demonstrate that the cleavage product of TRAF1 coimmunoprecipitates with TRAF2 that is released from the TNF-R1 complex in response to prolonged TNF treatment. These results indicate that caspase-dependent cleavage of TRAF1 generates TRAF1-c fragments that are able to bind TRAF2, and then sequester TRAF2 from the TNF-R1 complex, rendering cells, at least in part, sensitive to TNF. © 2001 Academic Press. | * |
dc.language | English | * |
dc.title | Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 281 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 499 | * |
dc.relation.lastpage | 505 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1006/bbrc.2001.4369 | * |
dc.identifier.wosid | WOS:000167262000037 | * |
dc.identifier.scopusid | 2-s2.0-0034803045 | * |
dc.author.google | Hyun Duk Jang | * |
dc.author.google | Young Mee Chung | * |
dc.author.google | Ji Hyun Baik | * |
dc.author.google | Young Geum Choi | * |
dc.author.google | Park I.-S. | * |
dc.author.google | Yong Keun Jung | * |
dc.author.google | Soo Young Lee | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |