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Synthesis and antiviral activity of novel D- and L-2′-azido-2′,3′-dideoxyribofuranosyl-4′- thiopyrimidines and purines

Title
Synthesis and antiviral activity of novel D- and L-2′-azido-2′,3′-dideoxyribofuranosyl-4′- thiopyrimidines and purines
Authors
Kim H.O.Kim Y.H.Suh H.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2001
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 11, no. 4, pp. 599 - 603
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Novel D- and L-2′-azido-2′,3′-dideoxyribofuranosyl-4′- thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-β-N6-methyladenine (ent-22a) and D-α-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity. © 2001 Elsevier Science Ltd.
DOI
10.1016/S0960-894X(01)00006-3
Appears in Collections:
약학대학 > 약학과 > Journal papers
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