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Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP

Title
Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP
Authors
Choi I.Y.Lee S.J.Nam W.Park J.-S.Ko K.H.Kim H.-C.Shin C.Y.Chung J.-H.Noh S.K.Choi C.-R.Shin D.-H.Kim W.-K.
Ewha Authors
남원우
SCOPUS Author ID
남원우scopus
Issue Date
2001
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728JCR Link
Citation
vol. 112, no. 1-2, pp. 55 - 62
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H2TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H2TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra. (C) 2001 Published by Elsevier Science B.V.
DOI
10.1016/S0165-5728(00)00382-9
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자연과학대학 > 화학·나노과학전공 > Journal papers
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