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Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Title
Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential
Authors
Ryu C.-K.Jeong H.-J.Lee S.K.Kang H.-Y.Ko K.-M.Sun Y.-J.Song E.-H.Hur Y.H.Lee C.-O.
Ewha Authors
유충규이상국
SCOPUS Author ID
유충규scopus
Issue Date
2000
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 23, no. 6, pp. 554 - 558
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.
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약학대학 > 약학과 > Journal papers
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