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Design and synthesis of α,β-unsaturated carbonyl compounds as potential ACE inhibitors

Title
Design and synthesis of α,β-unsaturated carbonyl compounds as potential ACE inhibitors
Authors
Choo H.-Y.P.Peak K.-H.Park J.Kim D.H.Chung H.S.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2000
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 35, no. 6, pp. 643 - 648
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The α,β-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
DOI
10.1016/S0223-5234(00)00158-6
Appears in Collections:
약학대학 > 약학과 > Journal papers
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