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7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

Title
7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines
Authors
Ryu C.-K.Lee I.-K.Jung S.-H.Kang H.-Y.Lee C.-O.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2000
Journal Title
Medicinal Chemistry Research
ISSN
1054-2523JCR Link
Citation
vol. 10, no. 1, pp. 40 - 49
Indexed
SCIE; SCOPUS WOS scopus
Abstract
6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
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약학대학 > 약학과 > Journal papers
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