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Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Title
Zinc increases the excitability of dopaminergic neurons in rat substantia nigra
Authors
Chung J.-M.Chang S.-Y.Kim Y.-I.Shin H.-C.
Ewha Authors
정준모
SCOPUS Author ID
정준모scopus
Issue Date
2000
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
vol. 286, no. 3, pp. 183 - 186
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.
DOI
10.1016/S0304-3940(00)01120-4
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자연과학대학 > 생명과학전공 > Journal papers
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