Bioorganic and Medicinal Chemistry Letters vol. 10, no. 5, pp. 461 - 464
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.