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5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

Title
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents
Authors
Ryu C.-K.Kang H.-Y.Lee S.K.Nam K.A.Hong C.Y.Ko W.-G.Lee B.-H.
Ewha Authors
유충규이상국
SCOPUS Author ID
유충규scopus
Issue Date
2000
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 10, no. 5, pp. 461 - 464
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.
DOI
10.1016/S0960-894X(00)00014-7
Appears in Collections:
약학대학 > 약학과 > Journal papers
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