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Effects of cyclosporin on the pharmacokinetics of propranolol after intravenous and oral administration to control rats and to rats with uranyl nitrate-induced acute renal failure

Title
Effects of cyclosporin on the pharmacokinetics of propranolol after intravenous and oral administration to control rats and to rats with uranyl nitrate-induced acute renal failure
Authors
Lee Y.H.Ku Y.S.
Ewha Authors
구영순
SCOPUS Author ID
구영순scopusscopus
Issue Date
1999
Journal Title
Journal of Pharmacy and Pharmacology
ISSN
0022-3573JCR Link
Citation
vol. 51, no. 10, pp. 1149 - 1154
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The effects of cyclosporin on the pharmacokinetics of propranolol have been investigated after intravenous and oral administration of the drugs to control rats and to rats with uranyl nitrate-induced acute renal failure. The effects of intravenous cyclosporin, 30 mg kg-1, on the pharmacokinetics of intravenous propranolol, 3 mg kg-1, were significant both in control rats and in rats with uranyl nitrate-induced acute renal failure, after intravenous administration of cyclosporin plasma concentrations of propranolol were significantly lower, the area under the plasma concentration-time curve (AUC) for propranolol from time zero to time infinity was significantly smaller, and the time-averaged total body clearance of propranolol was significantly faster. The effects of oral cyclosporin, 100 mg kg-1, on the pharmacokinetics of oral propranolol, 10 mg kg-1, were also significant, both in control rats and in rats with uranyl nitrate-induced acute renal failure. after administration of oral cyclosporin plasma concentrations of propranolol were significantly higher and the AUC of propranolol was significantly greater. These data suggest that cyclosporin increases the elimination of propranolol, and that the first-pass effects of propranolol are reduced, or gastrointestinal absorption of propranolol is increased, or both, by cyclosporin.
DOI
10.1211/0022357991776840
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약학대학 > 약학과 > Journal papers
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