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6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation

Title
6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation
Authors
Ryu C.-K.Jung S.-H.Lee J.-A.Kim H.-J.Lee S.-H.Chung J.-H.
Ewha Authors
유충규김화정
SCOPUS Author ID
유충규scopus; 김화정scopus
Issue Date
1999
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 9, no. 17, pp. 2469 - 2472
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.
DOI
10.1016/S0960-894X(99)00411-4
Appears in Collections:
약학대학 > 약학과 > Journal papers
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