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Structural determination of synthetic monoacetyldiglycerides by tandem mass spectrometry of sodium-adducted molecules

Title
Structural determination of synthetic monoacetyldiglycerides by tandem mass spectrometry of sodium-adducted molecules
Authors
Kim Y.H.Han S.-Y.Cho S.-H.Yoo J.S.Jhon G.-J.
Ewha Authors
전길자한소엽
SCOPUS Author ID
전길자scopus; 한소엽scopus
Issue Date
1999
Journal Title
Rapid Communications in Mass Spectrometry
ISSN
0951-4198JCR Link
Citation
vol. 13, no. 6, pp. 481 - 487
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A variety of synthetic monoacetyldiglycerides (MADGs), which show hematopoietic stem cell stimulating activity, were investigated using high-energy collision-induced dissociation (CID) tandem mass spectrometry (MS/MS) coupled with fast-atom bombardment (FAB). CID of sodium-adducted molecules, (M + Na]+, generated product ions highly informative on their structure. In particular, two type of ions (named E2,3 and J) and the relative intensity ratio (G2/G1) of two product ions (named G1 and G2) by the loss of free fatty acids (-R(n)/' COOH) provided definitive information about the position of two long-chain acyl groups on the glycerol backbone. In addition, charge-remote fragmentation (CRF) along the long hydrocarbon chains of two fatty acyl groups determined the position of each double bond. Thus, this direct and rapid method can be applied to the structural determination of individual molecular species in a mixture of MADGs isolated from biological origins.
DOI
10.1002/(SICI)1097-0231(19990330)13:6&lt481::AID-RCM511&gt3.0.CO2-K
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자연과학대학 > 화학·나노과학전공 > Journal papers
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