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Possible implication for an indirect interaction between basic fibroblast growth factor and (Na,K)ATPase

Title
Possible implication for an indirect interaction between basic fibroblast growth factor and (Na,K)ATPase
Authors
Oh J.Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림scopus
Issue Date
1998
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 21, no. 6, pp. 707 - 711
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The (Na,K)ATPase is responsible for generating the ionic gradients and membrane potentials by the exchange of intracellular Na+ for K+. It has been recently shown that (Na,K)ATPase is involved in the exocytic pathway of basic fibroblast growth factor (bFGF), although it is not known that bFGF is secreted to the outside of cell through direct interaction with (Na,K) ATPase. To understand the role for (Na,K)ATPase in the secretory pathway of bFGF, we have sought to identify the cytoplasmic domains of the α1 isoform of (Na,K)ATPase interacting with bFGF by yeast two-hybrid system. We have also investigated the interaction between the α2 isoform of (Na,K)ATPase and bFGF to find out whether the interaction is isoform-specific. We found that none of the cytoplasmic domains of (Na,K)ATPase isoforms interacted with bFGF. The result suggests that the interaction between bFGF and (Na,K)ATPase might be indirect, thus requiring other proteins which are involved in the formation of protein complexes for the interaction, although we cannot exclude the possibility that the interaction requires the element of the whole α subunit structure that was not present in the isolated α subunit cytoplasmic domains.
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약학대학 > 약학과 > Journal papers
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