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Epoxyalkanoyls as novel ACE inhibitors

Title
Epoxyalkanoyls as novel ACE inhibitors
Authors
Choo H.-Y.P.Yoon H.-R.Park H.-S.Kim D.-H.Park J.Kim D.H.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
1998
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 21, no. 2, pp. 168 - 173
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06∼5.5 μM.
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약학대학 > 약학과 > Journal papers
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