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Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease

Title
Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease
Authors
Kim, ChanghwanJung, Ji YeKim, Young SamLee, Jae SeungRhee, Chin KookLee, Jin HwaLee, Ji-HyunKim, Tae-HyungLim, Seong YongSheen, Seung SooYoo, Kwang HaSeo, Joon BeomOh, Yeon-MokLee, Sang-DoPark, Yong Bum
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2016
Journal Title
RESPIRATION
ISSN
0025-7931JCR Link1423-0356JCR Link
Citation
vol. 91, no. 5, pp. 351 - 358
Keywords
Chronic obstructive pulmonary diseaseVitamin D deficiencyExercise capacitySix-minute walk distance
Publisher
KARGER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity >= 17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. (C) 2016 S. Karger AG, Basel
DOI
10.1159/000445266
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의학전문대학원 > 의학과 > Journal papers
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