Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이진화 | * |
dc.date.accessioned | 2016-08-28T11:08:56Z | - |
dc.date.available | 2016-08-28T11:08:56Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0025-7931 | * |
dc.identifier.issn | 1423-0356 | * |
dc.identifier.other | OAK-18936 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218336 | - |
dc.description.abstract | Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity >= 17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. (C) 2016 S. Karger AG, Basel | * |
dc.language | English | * |
dc.publisher | KARGER | * |
dc.subject | Chronic obstructive pulmonary disease | * |
dc.subject | Vitamin D deficiency | * |
dc.subject | Exercise capacity | * |
dc.subject | Six-minute walk distance | * |
dc.title | Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 91 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 351 | * |
dc.relation.lastpage | 358 | * |
dc.relation.journaltitle | RESPIRATION | * |
dc.identifier.doi | 10.1159/000445266 | * |
dc.identifier.wosid | WOS:000377991300001 | * |
dc.identifier.scopusid | 2-s2.0-84975256325 | * |
dc.author.google | Kim, Changhwan | * |
dc.author.google | Jung, Ji Ye | * |
dc.author.google | Kim, Young Sam | * |
dc.author.google | Lee, Jae Seung | * |
dc.author.google | Rhee, Chin Kook | * |
dc.author.google | Lee, Jin Hwa | * |
dc.author.google | Lee, Ji-Hyun | * |
dc.author.google | Kim, Tae-Hyung | * |
dc.author.google | Lim, Seong Yong | * |
dc.author.google | Sheen, Seung Soo | * |
dc.author.google | Yoo, Kwang Ha | * |
dc.author.google | Seo, Joon Beom | * |
dc.author.google | Oh, Yeon-Mok | * |
dc.author.google | Lee, Sang-Do | * |
dc.author.google | Park, Yong Bum | * |
dc.contributor.scopusid | 이진화(56646645800;58376333800) | * |
dc.date.modifydate | 20240419140935 | * |