Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이진규 | * |
dc.date.accessioned | 2016-08-27T04:08:12Z | - |
dc.date.available | 2016-08-27T04:08:12Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1748-6041 | * |
dc.identifier.issn | 1748-605X | * |
dc.identifier.other | OAK-18597 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218215 | - |
dc.description.abstract | The aim of this study is to fabricate lactoferrin (LF)-carrying hydroxyapatite nanoparticles (HAp NPs) to enhance osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs). HAp NPs were modified with heparin-dopamine (Hep-DOPA) (Hep-HAp) and further immobilized with LF (LF/Hep-HAp). Heparin immobilization on HAp NPs prevented aggregation of HAp NPs in aqueous solution and prolonged the release of LF from LF/Hep-HAp NPs. In vitro studies of rADSCs have demonstrated that LF-Hep/HAp NPs significantly increase alkaline phosphatase (ALP) activity, calcium deposition, and both mRNA expression of osteocalcin (OCN) and osteopontin (OPN) in comparison with HAp and Hep-HAp NPs. These results suggest that LF/Hep-HAp NPs can effectively induce osteogenic differentiation of rADSCs. | * |
dc.language | English | * |
dc.publisher | IOP PUBLISHING LTD | * |
dc.subject | hydroxyapatite nanoparticles | * |
dc.subject | heparin | * |
dc.subject | lactoferrin delivery | * |
dc.subject | adipose-derived stem cells | * |
dc.subject | osteogenic differentiation | * |
dc.title | Heparin-immobilized hydroxyapatite nanoparticles as a lactoferrin delivery system for improving osteogenic differentiation of adipose-derived stem cells | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BIOMEDICAL MATERIALS | * |
dc.identifier.doi | 10.1088/1748-6041/11/2/025004 | * |
dc.identifier.wosid | WOS:000375523400009 | * |
dc.identifier.scopusid | 2-s2.0-84964523953 | * |
dc.author.google | Kim, Sung Eun | * |
dc.author.google | Lee, Deok-Won | * |
dc.author.google | Yun, Young-Pil | * |
dc.author.google | Shim, Kyu-Sik | * |
dc.author.google | Jeon, Daniel I. | * |
dc.author.google | Rhee, Jin-Kyu | * |
dc.author.google | Kim, Hak-Jun | * |
dc.author.google | Park, Kyeongsoon | * |
dc.contributor.scopusid | 이진규(56599780300) | * |
dc.date.modifydate | 20240322121516 | * |