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Changes in one-carbon metabolism after duodenal-jejunal bypass surgery

Title
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery
Authors
Jung J.Ha T.K.Lee J.Lho Y.Nam M.Lee D.Le Roux C.W.Ryu D.H.Ha E.Hwang G.-S.
Ewha Authors
황금숙
SCOPUS Author ID
황금숙scopusscopus
Issue Date
2016
Journal Title
American Journal of Physiology - Endocrinology and Metabolism
ISSN
0193-1849JCR Link
Citation
vol. 310, no. 8, pp. E624 - E632
Keywords
Gastric bypass surgeryMetabolismMetabolomicsProteomics
Publisher
American Physiological Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Bariatric surgery alleviates obesity and ameliorates glucose tolerance. Using metabolomic and proteomic profiles, we evaluated metabolic changes in serum and liver tissue after duodenal-jejunal bypass (DJB) surgery in rats fed a normal chow diet. We found that the levels of vitamin B12 in the sera of DJB rates were decreased. In the liver of DJB rats, betaine-homocysteine S-methyltransferase levels were decreased, whereas serine, cystathionine, cysteine, glutathione, cystathionine-synthase, glutathione S-transferase, and aldehyde dehydrogenase levels were increased. These results suggested that DJB surgery enhanced trans-sulfuration and its consecutive reactions such as detoxification and the scavenging activities of reactive oxygen species. In addition, DJB rats showed higher levels of purine metabolites such as ATP, ADP, AMP, and inosine monophosphate. Decreased guanine deaminase, as well as lower levels of hypoxanthine, indicated that DJB surgery limited the purine degradation process. In particular, the AMP/ATP ratio and phosphorylation of AMP-activated protein kinase increased after DJB surgery, which led to enhanced energy production and increased catabolic pathway activity, such as fatty acid oxidation and glucose transport. This study shows that bariatric surgery altered trans-sulfuration and purine metabolism in the liver. Characterization of these mechanisms increases our understanding of the benefits of bariatric surgery. © 2016 the American Physiological Society.
DOI
10.1152/ajpendo.00260.2015
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자연과학대학 > 화학·나노과학전공 > Journal papers
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