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Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Title
Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
Authors
Sugawara, ReikoLee, Eun-JungJang, Min SeongJeun, Eun-JiHong, Chun-PyoKim, Jung-HwanPark, AreumYun, Chang HoHong, Sung-WookKim, You-MeSeoh, Ju-YoungJung, YunJaeSurh, Charles D.Miyasaka, MasayukiYang, Bo-GieJang, Myoung Ho
Ewha Authors
서주영
SCOPUS Author ID
서주영scopus
Issue Date
2016
Journal Title
JOURNAL OF EXPERIMENTAL MEDICINE
ISSN
0022-1007JCR Link1540-9538JCR Link
Citation
vol. 213, no. 4, pp. 555 - 567
Publisher
ROCKEFELLER UNIV PRESS
Indexed
SCI; SCIE WOS
Abstract
Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.
DOI
10.1084/jem.20141388
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의과대학 > 의학과 > Journal papers
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