Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서주영 | - |
dc.date.accessioned | 2016-08-27T04:08:07Z | - |
dc.date.available | 2016-08-27T04:08:07Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.issn | 1540-9538 | - |
dc.identifier.other | OAK-18449 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218172 | - |
dc.description.abstract | Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 213 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.startpage | 555 | - |
dc.relation.lastpage | 567 | - |
dc.relation.journaltitle | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.identifier.doi | 10.1084/jem.20141388 | - |
dc.identifier.wosid | WOS:000373394100008 | - |
dc.author.google | Sugawara, Reiko | - |
dc.author.google | Lee, Eun-Jung | - |
dc.author.google | Jang, Min Seong | - |
dc.author.google | Jeun, Eun-Ji | - |
dc.author.google | Hong, Chun-Pyo | - |
dc.author.google | Kim, Jung-Hwan | - |
dc.author.google | Park, Areum | - |
dc.author.google | Yun, Chang Ho | - |
dc.author.google | Hong, Sung-Wook | - |
dc.author.google | Kim, You-Me | - |
dc.author.google | Seoh, Ju-Young | - |
dc.author.google | Jung, YunJae | - |
dc.author.google | Surh, Charles D. | - |
dc.author.google | Miyasaka, Masayuki | - |
dc.author.google | Yang, Bo-Gie | - |
dc.author.google | Jang, Myoung Ho | - |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | - |
dc.date.modifydate | 20230210140937 | - |