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Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus

Title
Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus
Authors
Song, SoonhwaLee, Jae-JinKim, Hee-JungLee, Jeong YoonChang, JunLee, Kong-Joo
Ewha Authors
이공주장준김희정이제진
SCOPUS Author ID
이공주scopus; 장준scopus; 김희정scopusscopusscopus; 이제진scopus
Issue Date
2016
Journal Title
MOLECULAR AND CELLULAR BIOLOGY
ISSN
0270-7306JCR Link1098-5549JCR Link
Citation
vol. 36, no. 7, pp. 1136 - 1151
Publisher
AMER SOC MICROBIOLOGY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
This study is designed to examine the cellular functions of human Fas-associated factor 1 (FAF1) containing multiple ubiquitinrelated domains. Microarray analyses revealed that interferon-stimulated genes related to the antiviral response are significantly increased in FAF1-knockdown HeLa cells. Silencing FAF1 enhanced the poly(I.C)- and respiratory syncytial virus (RSV)-induced production of type I interferons (IFNs), the target genes of interferon regulator factor 3 (IRF3). IRF3 is a key transcription factor in IFN-beta signaling responsible for the host innate immune response. This study also found that FAF1 and IRF3 physically associate with IPO5/importin-beta 3 and that overexpression of FAF1 reduces the interaction between IRF3 and IPO5/importin-beta 3. These findings suggest that FAF1 negatively regulates IRF3-mediated IFN-beta production and the antiviral innate immune response by regulating nuclear translocation of IRF3. We conclude that FAF1 plays a novel role in negatively regulating virus-induced IFN-beta production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus.
DOI
10.1128/MCB.00744-15
Appears in Collections:
약학대학 > 약학과 > Journal papers
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