Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류재상 | * |
dc.date.accessioned | 2016-08-27T04:08:05Z | - |
dc.date.available | 2016-08-27T04:08:05Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.issn | 1464-3391 | * |
dc.identifier.other | OAK-18398 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218147 | - |
dc.description.abstract | A series of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives were designed, synthesized, and evaluated for the Aurora kinase inhibitory activities. The novel hinge-binder tethered 1,2,3-triazolylsalicylamide scaffold was effectively assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). A variety of alkynes with hinge binders were used to search proper structures-binding relationship to the hinge region. The synthesized 1,2,3-triazolylsalicylamide derivatives showed significant Aurora kinase inhibitory activity. In particular, 8a inhibited Aurora A kinase with an IC50 value of 0.284 mu M, whereas 8m inhibited Aurora B kinase with an IC50 value of 0.364 mu M. (C) 2016 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Aurora kinase | * |
dc.subject | Click chemistry | * |
dc.subject | Hinge-binder | * |
dc.subject | 1,2,3-Triazole | * |
dc.subject | Anticancer | * |
dc.title | Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2114 | * |
dc.relation.lastpage | 2124 | * |
dc.relation.journaltitle | BIOORGANIC & MEDICINAL CHEMISTRY | * |
dc.identifier.doi | 10.1016/j.bmc.2016.03.042 | * |
dc.identifier.wosid | WOS:000373740500014 | * |
dc.identifier.scopusid | 2-s2.0-84962052750 | * |
dc.author.google | Jeong, Yunkyung | * |
dc.author.google | Lee, Jooyeon | * |
dc.author.google | Ryu, Jae-Sang | * |
dc.contributor.scopusid | 류재상(36081118200) | * |
dc.date.modifydate | 20231120165709 | * |