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Oligonucleotide-based biosensors for in vitro diagnostics and environmental hazard detection

Title
Oligonucleotide-based biosensors for in vitro diagnostics and environmental hazard detection
Authors
Jung, Il YoungLee, Eun HeeSuh, Ah YoungLee, Seung JinLee, Hyukjin
Ewha Authors
이승진이혁진
SCOPUS Author ID
이승진scopus; 이혁진scopus
Issue Date
2016
Journal Title
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN
1618-2642JCR Link1618-2650JCR Link
Citation
vol. 408, no. 10, pp. 2383 - 2406
Keywords
BiosensorsOligonucelotideIn vitro diagnosisEnvironmental harzard detection
Publisher
SPRINGER HEIDELBERG
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Oligonucleotide-based biosensors have drawn much attention because of their broad applications in in vitro diagnostics and environmental hazard detection. They are particularly of interest to many researchers because of their high specificity as well as excellent sensitivity. Recently, oligonucleotide-based biosensors have been used to achieve not only genetic detection of targets but also the detection of small molecules, peptides, and proteins. This has further broadened the applications of these sensors in the medical and health care industry. In this review, we highlight various examples of oligonucleotide-based biosensors for the detection of diseases, drugs, and environmentally hazardous chemicals. Each example is provided with detailed schematics of the detection mechanism in addition to the supporting experimental results. Furthermore, future perspectives and new challenges in oligonucleotide-based biosensors are discussed.
DOI
10.1007/s00216-015-9212-2
Appears in Collections:
약학대학 > 약학과 > Journal papers
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