Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박진병 | * |
dc.contributor.author | 권용억 | * |
dc.date.accessioned | 2016-08-27T04:08:55Z | - |
dc.date.available | 2016-08-27T04:08:55Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1463-9262 | * |
dc.identifier.issn | 1463-9270 | * |
dc.identifier.other | OAK-16504 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218053 | - |
dc.description.abstract | A practical chemoenzymatic synthetic method for 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid (12-hydroxyoleic acid) was investigated. Biotransformation of ricinoleic acid into the ester (3) via 12-ketooleic acid (2) was driven by recombinant Escherichia coli cells expressing an alcohol dehydrogenase from Micrococcus luteus and the Baeyer-Villiger monooxygenase from Pseudomonas putida KT2440. The carbon-carbon double bond of the ester (3) was chemically reduced, and the ester bond was hydrolyzed to afford n-heptanoic acid (5) and 11-hydroxyundecanoic acid (7), which were converted into other related derivatives. For example, 11-hydroxyundecanoic acid was transformed into 1,11-undecanedioic acid (8) under fairly mild reaction conditions. Whole-cell biotransformation at high cell density (i.e., 20 g dry cells per L) allowed the final ester product concentration and volumetric productivity to reach 53 mM and 6.6 mM h(-1), respectively. The overall molar yield of 1,11-undecanedioic acid from ricinoleic acid was 55% based on the biotransformation and chemical transformation conversion yields of 84% and 65%, respectively. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | Chemo-enzymatic synthesis of 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1089 | * |
dc.relation.lastpage | 1095 | * |
dc.relation.journaltitle | GREEN CHEMISTRY | * |
dc.identifier.doi | 10.1039/c5gc01017a | * |
dc.identifier.wosid | WOS:000370617600025 | * |
dc.author.google | Jang, Hyun-Young | * |
dc.author.google | Singha, Kaushik | * |
dc.author.google | Kim, Hwan-Hee | * |
dc.author.google | Kwon, Yong-Uk | * |
dc.author.google | Park, Jin-Byung | * |
dc.contributor.scopusid | 박진병(15036390700) | * |
dc.contributor.scopusid | 권용억(7403459303) | * |
dc.date.modifydate | 20240322114808 | * |