Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2016-08-27T04:08:53Z | - |
dc.date.available | 2016-08-27T04:08:53Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-16455 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218032 | - |
dc.description.abstract | Alisma canaliculatum is a herb commonly used in traditional Korean medicine, and has been shown in scientific studies to have antitumor, diuretic hepatoprotective, and antibacterial effects. Recently, the anti-osteoclastogenesis of alisol A 24-acetate from Alisma canaliculatum was investigated in vitro. However, the influence of alisol A 24-acetate on osteoporosis in animals has not been investigated. The present study was undertaken to investigate the anti-osteoporotic effect of alisol A 24-acetate on bone mass in ovariectomized (OVX) mice and to identify the mechanism responsible for its effects. OVX mice were treated daily with 0.5 or 2 μg/g of alisol A 24-acetate for a period of six weeks. It was found that these administrations significantly suppressed osteoporosis in OVX mice and improved bone morphometric parameters. The serum estradiol, bone alkaline phosphatase levels, regulatory T/Th17 cell numbers were significantly increased by alisol A 24-acetate as compared with untreated OVX mice. In addition, TRAP activity was inhibited by alisol A 24-acetate in OVX mice. These results suggest alisol A 24-acetate effectively prevents bone loss in OVX mice, and that it can be considered a potential therapeutic for the treatment of postmenopausal osteoporosis. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | Alisma canaliculatum | * |
dc.subject | Alisol a 24-acetate | * |
dc.subject | Bone loss | * |
dc.subject | Osteoporosis | * |
dc.subject | Regulator t cell | * |
dc.subject | Traditional Korean medicine | * |
dc.title | The protective effects of alisol a 24-Acetate from alisma canaliculatum on ovariectomy induced bone loss in vivo | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Molecules | * |
dc.identifier.doi | 10.3390/molecules21010074 | * |
dc.identifier.wosid | WOS:000369486800058 | * |
dc.identifier.scopusid | 2-s2.0-85000692244 | * |
dc.author.google | Hwang Y.-H. | * |
dc.author.google | Kang K.-Y. | * |
dc.author.google | Lee S.-J. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Son Y.-J. | * |
dc.author.google | Yee S.-T. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |