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Anionic clay as the drug delivery vehicle: tumor targeting function of layered double hydroxide-methotrexate nanohybrid in C33A orthotopic cervical cancer model

Title
Anionic clay as the drug delivery vehicle: tumor targeting function of layered double hydroxide-methotrexate nanohybrid in C33A orthotopic cervical cancer model
Authors
Choi, GoeunPiao, HuiyanAlothman, Zeid A.Vinu, AjayanYun, Chae-OkChoy, Jin-Ho
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2016
Journal Title
INTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN
1178-2013JCR Link
Citation
vol. 11, pp. 337 - 348
Keywords
anionic claybiodistributioncervical cancercolloidal stabilitylayered double hydroxidemethotrexate
Publisher
DOVE MEDICAL PRESS LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Methotrexate (MTX), an anticancer agent, was successfully intercalated into the anionic clay, layered double hydroxides to form a new nanohybrid drug. The coprecipitation and subsequent hydrothermal method were used to prepare chemically, structurally, and morphologically well-defined two-dimensional drug-clay nanohybrid. The resulting two-dimensional drug-clay nanohybrid showed excellent colloidal stability not only in deionized water but also in an electrolyte solution of Dulbecco's Modified Eagle's Medium with 10% fetal bovine serum, in which the average particle size in colloid and the polydispersity index were determined to be around 100 and 0.250 nm, respectively. The targeting property of the nanohybrid drug was confirmed by evaluating the tumor-to-blood and tumor-to-liver ratios of the MTX with anionic clay carrier, and these ratios were compared to those of free MTX in the C33A orthotopic cervical cancer model. The biodistribution studies indicated that the mice treated with the former showed 3.5-fold higher tumor-to-liver ratio and fivefold higher tumor-to-blood ratio of MTX than those treated with the latter at 30 minutes postinjection.
DOI
10.2147/IJN.S95611
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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