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Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells

Title
Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells
Authors
Han, Sang HeeKim, JusongHer, YerimSeong, IkjooPark, SeraBhattarai, DeepakJin, GuanghaiLee, KyeongChung, GukhoonHwang, SungkeeBae, Yun SooKim, Jaesang
Ewha Authors
배윤수김재상
SCOPUS Author ID
배윤수scopus; 김재상scopus
Issue Date
2015
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link1976-670XJCR Link
Citation
vol. 48, no. 12, pp. 691 - 695
Keywords
K562MegakaryocytePhytosphingosinePlatelet(R)-TEMOSPho
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
We report that phytosphingosine, a sphingolipid found in many organisms and implicated in cellular signaling, promotes megakaryocytic differentiation of myeloid leukemia cells. Specifically, phytosphingosine induced several hallmark changes associated with megakaryopoiesis from K562 and HEL cells including cell cycle arrest, cell size increase and polyploidization. We also confirmed that cell type specific markers of megakaryocytes, CD41a and CD42b are induced by phytosphingosine. Phospholipids with highly similar structures were unable to induce similar changes, indicating that the activity of phytosphingosine is highly specific. Although phytosphingosine is known to activate p38 mitogen-activated protein kinase (MAPK)-mediated apoptosis, the signaling mechanisms involved in megakaryopoiesis appear to be distinct. In sum, we present another model for dissecting molecular details of megakaryocytic differentiation which in large part remains obscure.
DOI
10.5483/BMBRep.2015.48.12.100
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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