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Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment

Title
Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment
Authors
Jo, Mun JeongPaek, A. RomeChoi, Ji SeungOk, Chang YoupJeong, Kyung ChaeLim, Jae HyangKim, Seok HyunYou, Hye Jin
Ewha Authors
임재향
SCOPUS Author ID
임재향scopus
Issue Date
2015
Journal Title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN
0014-2999JCR Link1879-0712JCR Link
Citation
vol. 769, pp. 257 - 265
Keywords
c-MycApoptosisCaspase-3Cancer
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
The proto-oncogene c-Myc has been implicated in a variety of cellular processes, such as proliferation, differentiation and apoptosis. Several c-Myc targets have been studied; however, selective regulation of c-Myc is not easy in cancer cells. Herein, we attempt to identify chemical compounds that induce cell death in c-Myc-overexpressing cells (STF-cMyc and STF-Control) by conducting MTS assays on approximately 4000 chemical compounds. One compound, C604, induced cell death in STF-cMyc cells but not STF-Control cells. Apoptotic proteins, including caspase-3 and poly(ADP-ribose) polymerase (PAPP), were cleaved in C604-treated STF-cMyc cells. In addition, 5W620, HCT116 and NCI-H23 cells, which exhibit higher basal levels of c-Myc, underwent apoptotic cell death in response to C604, suggesting a role for C604 as an inducer of apoptosis in cancer cells with c-Myc amplification. C604 induced cell cycle arrest at the G2/M phase in cells, which was not affected by apoptotic inhibitors. Interestingly, C604 induced accumulation of c-Myc and Cdc25A proteins. In summary, a chemical compound was identified that may induce cell death in cancer cells with c-Myc amplification specifically through an apoptotic pathway. (C) 2015 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ejphar.2015.11.027
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의학전문대학원 > 의학과 > Journal papers
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