Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 임재향 | * |
dc.date.accessioned | 2016-08-27T04:08:38Z | - |
dc.date.available | 2016-08-27T04:08:38Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0014-2999 | * |
dc.identifier.issn | 1879-0712 | * |
dc.identifier.other | OAK-16115 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217886 | - |
dc.description.abstract | The proto-oncogene c-Myc has been implicated in a variety of cellular processes, such as proliferation, differentiation and apoptosis. Several c-Myc targets have been studied; however, selective regulation of c-Myc is not easy in cancer cells. Herein, we attempt to identify chemical compounds that induce cell death in c-Myc-overexpressing cells (STF-cMyc and STF-Control) by conducting MTS assays on approximately 4000 chemical compounds. One compound, C604, induced cell death in STF-cMyc cells but not STF-Control cells. Apoptotic proteins, including caspase-3 and poly(ADP-ribose) polymerase (PAPP), were cleaved in C604-treated STF-cMyc cells. In addition, 5W620, HCT116 and NCI-H23 cells, which exhibit higher basal levels of c-Myc, underwent apoptotic cell death in response to C604, suggesting a role for C604 as an inducer of apoptosis in cancer cells with c-Myc amplification. C604 induced cell cycle arrest at the G2/M phase in cells, which was not affected by apoptotic inhibitors. Interestingly, C604 induced accumulation of c-Myc and Cdc25A proteins. In summary, a chemical compound was identified that may induce cell death in cancer cells with c-Myc amplification specifically through an apoptotic pathway. (C) 2015 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | c-Myc | * |
dc.subject | Apoptosis | * |
dc.subject | Caspase-3 | * |
dc.subject | Cancer | * |
dc.title | Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment | * |
dc.type | Article | * |
dc.relation.volume | 769 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 257 | * |
dc.relation.lastpage | 265 | * |
dc.relation.journaltitle | EUROPEAN JOURNAL OF PHARMACOLOGY | * |
dc.identifier.doi | 10.1016/j.ejphar.2015.11.027 | * |
dc.identifier.wosid | WOS:000366137800032 | * |
dc.author.google | Jo, Mun Jeong | * |
dc.author.google | Paek, A. Rome | * |
dc.author.google | Choi, Ji Seung | * |
dc.author.google | Ok, Chang Youp | * |
dc.author.google | Jeong, Kyung Chae | * |
dc.author.google | Lim, Jae Hyang | * |
dc.author.google | Kim, Seok Hyun | * |
dc.author.google | You, Hye Jin | * |
dc.contributor.scopusid | 임재향(7403454262) | * |
dc.date.modifydate | 20240220101019 | * |