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Phosphorylcholine-Based Zwitterionic Biocompatible Thermogel

Title
Phosphorylcholine-Based Zwitterionic Biocompatible Thermogel
Authors
Ko, Du YoungPatel, MadhumitaJung, Bo KyoengPark, Jin HyeJeong, Byeongmoon
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2015
Journal Title
BIOMACROMOLECULES
ISSN
1525-7797JCR Link1526-4602JCR Link
Citation
vol. 16, no. 12, pp. 3853 - 3862
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Zwitterionic polymers have been investigated as surface-coating materials due to their low protein adsorption properties, which reduce immunogenicity, biofouling, and bacterial adsorption of coated materials. Most zwitterionic polymers, reported so far, are based on (meth)acrylate polymers which can induce toxicity by residual monomers or amines produced by degradation. Here, we report a new zwitterionic polymer consisting of phosphorylcholine (PC) and biocompatible poly-(propylene glycol) (PPG) as a new thermogelling material. The PC-PPG-PC polymer aqueous solution undergoes unique multiple sol-gel transitions as the temperature increases. A heat-induced unirner-to-micelle transition, changes in ionic interactions, and dehydration of PPG are involved in the sol-gel transitions. Based on the broad gel window and low protein adsorption properties, the PC-PPG-PC thermogel is proved for sustained delivery of protein drugs and stem cells over 1 week.
DOI
10.1021/acs.biomac.5b01169
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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