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Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis

Title
Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis
Authors
Leutou, Alain S.Yang, InhoKang, HeonjoongSeo, Eun KyungNam, Sang-JipFenical, William
Ewha Authors
서은경남상집
SCOPUS Author ID
서은경scopus; 남상집scopus
Issue Date
2015
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link1520-6025JCR Link
Citation
vol. 78, no. 11, pp. 2846 - 2849
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.
DOI
10.1021/acs.jnatprod.5b00746
Appears in Collections:
약학대학 > 약학과 > Journal papers
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