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Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency

Title
Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency
Authors
Son, Ga-HyunYou, Young-AhKwon, Eun-JinLee, Keun-YoungKim, Young Ju
Ewha Authors
김영주유영아
SCOPUS Author ID
김영주scopus; 유영아scopus
Issue Date
2016
Journal Title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN
1046-7408JCR Link1600-0897JCR Link
Citation
vol. 75, no. 2, pp. 155 - 161
Keywords
Amniotic fluidcervical insufficiencycytokine
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Problem Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid. Method of study A retrospective cohort study enrolled 71 patients undergoing physical examination-indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre-term birth (<= 32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay. Results Sixty-seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty-eight (56.7%) patients delivered pre-term. Of these, 26 (38.8%) were spontaneous very pre-term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin-1 beta (IL-1 beta), IL-6, IL-7, IL-15, IL-17 alpha, tumour necrosis factor-alpha (TNF-alpha), MIP-1 alpha, and MIP-1 beta were higher in patients with a very pre-term delivery than in those with a late pre-term delivery. IL-1 beta, IL-6, IL-7, IL-17 alpha, TNF-alpha, and cervical dilation were independently associated with a very pre-term birth. Conclusion Intra-amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre-term birth in women with cervical insufficiency.
DOI
10.1111/aji.12451
Appears in Collections:
의과대학 > 의학과 > Journal papers
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