Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영주 | * |
dc.contributor.author | 유영아 | * |
dc.date.accessioned | 2016-08-27T04:08:31Z | - |
dc.date.available | 2016-08-27T04:08:31Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1046-7408 | * |
dc.identifier.issn | 1600-0897 | * |
dc.identifier.other | OAK-15990 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217816 | - |
dc.description.abstract | Problem Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid. Method of study A retrospective cohort study enrolled 71 patients undergoing physical examination-indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre-term birth (<= 32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay. Results Sixty-seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty-eight (56.7%) patients delivered pre-term. Of these, 26 (38.8%) were spontaneous very pre-term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin-1 beta (IL-1 beta), IL-6, IL-7, IL-15, IL-17 alpha, tumour necrosis factor-alpha (TNF-alpha), MIP-1 alpha, and MIP-1 beta were higher in patients with a very pre-term delivery than in those with a late pre-term delivery. IL-1 beta, IL-6, IL-7, IL-17 alpha, TNF-alpha, and cervical dilation were independently associated with a very pre-term birth. Conclusion Intra-amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre-term birth in women with cervical insufficiency. | * |
dc.language | English | * |
dc.publisher | WILEY-BLACKWELL | * |
dc.subject | Amniotic fluid | * |
dc.subject | cervical insufficiency | * |
dc.subject | cytokine | * |
dc.title | Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 75 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 155 | * |
dc.relation.lastpage | 161 | * |
dc.relation.journaltitle | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | * |
dc.identifier.doi | 10.1111/aji.12451 | * |
dc.identifier.wosid | WOS:000370157900009 | * |
dc.identifier.scopusid | 2-s2.0-84956780868 | * |
dc.author.google | Son, Ga-Hyun | * |
dc.author.google | You, Young-Ah | * |
dc.author.google | Kwon, Eun-Jin | * |
dc.author.google | Lee, Keun-Young | * |
dc.author.google | Kim, Young Ju | * |
dc.contributor.scopusid | 김영주(55801681000) | * |
dc.contributor.scopusid | 유영아(35212686400) | * |
dc.date.modifydate | 20240429111118 | * |