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Efficient singlet oxygen generation from sugar pendant C-60 derivatives for photodynamic therapy

Title
Efficient singlet oxygen generation from sugar pendant C-60 derivatives for photodynamic therapy
Authors
Yano, ShigenobuNaemura, MasamiToshimitsu, AkioAkiyama, MotofusaIkeda, AtsushiKikuchi, Jun-ichiShen, XiandeDuan, QianNarumi, AtsushiInoue, MasahiroOhkubo, KeiFukuzumi, Shunichi
Ewha Authors
Shunichi FukuzumiKei Okubo
SCOPUS Author ID
Shunichi Fukuzumiscopus; Kei Okuboscopus
Issue Date
2015
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
1359-7345JCR Link1364-548XJCR Link
Citation
vol. 51, no. 93, pp. 16605 - 16608
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The amidation reaction between C-60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C-60 compound (3). The water soluble deacetylated compound, Glc-pendant C-60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.
DOI
10.1039/c5cc07353g
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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