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Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice

Title
Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice
Authors
Jeong, Se-JinPark, Jong-GilKim, SinaiKweon, Hyae YonSeo, SeungwoonNa, Dae-SeungLee, DonghoHong, Cheol YiNa, Chun-SooDong, Mi-SookOh, Goo Taeg
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2015
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link1976-3786JCR Link
Citation
vol. 38, no. 11, pp. 2049 - 2058
Keywords
Rhus verniciflua stokes (RVS)HyperlipidemiaBile acid biosynthesisLiver X receptor alpha (LXR alpha)Cyp7a1
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXR alpha. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.
DOI
10.1007/s12272-015-0579-6
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자연과학대학 > 생명과학전공 > Journal papers
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