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Sensing and antibacterial activity of imidazolium-based conjugated polydiacetylenes

Title
Sensing and antibacterial activity of imidazolium-based conjugated polydiacetylenes
Authors
Lee, SongyiCheng, HuaChi, MeiyingXu, QinglingChen, XiaoqiangEom, Chi-YongJames, Tony D.Park, SungsuYoon, Juyoung
Ewha Authors
윤주영Qingling Xu
SCOPUS Author ID
윤주영scopus
Issue Date
2016
Journal Title
BIOSENSORS & BIOELECTRONICS
ISSN
0956-5663JCR Link1873-4235JCR Link
Citation
vol. 77, pp. 1016 - 1019
Keywords
Antibacterial effectPolydiacetylenesColorimetric sensorFluorescent sensorProbe-killer
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the current study, we report the first example of polydiacetylenes (PDAs), where our PDA-based system acts as both a sensing probe and killer for bacteria. The contact of imidazolium and imidazole-derived PDA with various bacterial strains including MRSA (methicillin-resistant Staphylococcus aureus) and ESBL-EC (extended-spectrum beta-lactamase-producing Escherichia col results in a distinct blue-to-red calorimetric change of the solution as well as a rapid disruption of the bacterial membrane, which is demonstrated by transmission electron microscopy and confocal microscopy. Zeta potential analysis supports that antibacterial activity of the PDA solution originates from an electrostatic interaction between the negatively charged bacterial cell surface and the positively charged polymers. These results suggest that the PDA has a great potential to carry out the dual roles of a probe and killer for bacteria. (C) 2015 Elsevier B.V. All rights reserved.
DOI
10.1016/j.bios.2015.10.090
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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