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Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines

Title
Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines
Authors
Choi, Song HeePark, Byoung KwonLee, Keun-WookChang, JunLee, YoungheeKwon, Hyung-Joo
Ewha Authors
장준
SCOPUS Author ID
장준scopus
Issue Date
2015
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link1976-670XJCR Link
Citation
vol. 48, no. 10, pp. 565 - 570
Keywords
ApoptosisCell growthHepatocellular carcinomaOncolytic effectRSV
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
In several reports, the respiratory syncytial virus (RSV) was identified as an oncolytic virus in cancer cells (e.g., lung and prostate cancer). However, the effects of RSV in hepatocellular carcinoma (HCC) cells have not yet been investigated. Here, we observed the inhibitory effects of RSV infection in HCC cell-lines. Cell growth was significantly decreased by RSV infection in BNL-HCC, Hep3B, Huh-7 and SNU-739 cells. After RSV infection, plaque formation and syncytial formation were observed in affected Hep3B and Huh-7 cells. RSV protein-expression was also detected in Hep3B and Huh-7 cells; however, only Huh-7 cells showed apoptosis after RSV infection. Furthermore, inhibition of cell migration by RSV infection was observed in BNL-HCC, Hep3B, Huh-7 and SNU-739 cells. Therefore, further investigation is required to clarify the molecular mechanism of RSV-mediated inhibition of HCC cell growth, and to develop potential RSV oncolytic viro-therapeutics.
DOI
10.5483/BMBRep.2015.48.10.268
Appears in Collections:
약학대학 > 약학과 > Journal papers
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